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Gene Therapy Eyedrops Bring Hope to a Teen with Rare Genetic Condition

Imagine living with blurry vision, unable to see the world clearly. For 14-year-old Antonio, this was his reality due to a rare genetic condition called dystrophic epidermolysis bullosa. This condition not only caused painful blisters all over his body but also clouded his eyes with scarring, severely impairing his vision. But thanks to a groundbreaking treatment, Antonio’s sight has been restored, bringing hope not only to him but to millions of others with similar eye diseases.

Dr. Alfonoso Sabater, a skilled and compassionate doctor, treated Antonio using innovative gene therapy eyedrops. Before the treatment, Antonio’s eyes were covered in cloudy scars, making it difficult for him to see clearly. Dr. Sabater decided to adapt a gene therapy gel that had shown promising results in treating Antonio’s skin lesions, hoping it could be reformulated to help his eyes.

The treatment, known as Vyjuvek, utilizes an inactivated herpes simplex virus to deliver working copies of a gene that produces a protein called collagen 7. This protein plays a crucial role in maintaining the structure of both the skin and the corneas of the eyes. By delivering the functional gene through eyedrops, the therapy aimed to repair the damage caused by the genetic mutation responsible for Antonio’s condition.

After rigorous testing and obtaining necessary approvals, Antonio underwent surgery on his right eye, followed by regular treatment with the gene therapy eyedrops. Remarkably, his eye recovered from the surgery without scarring, and his vision showed significant improvement each month. Recently, doctors measured his vision at an impressive 20/25 in his right eye.

Buoyed by the success, Dr. Sabater began treating Antonio’s left eye, which had even more scar tissue. Encouragingly, this eye also displayed steady improvement, measuring close to 20/50 – a substantial leap from its previous state. For Antonio, this means a world of difference. He can now engage in activities he had longed for, such as playing video games with his friends, and he feels safer when moving around independently.

Antonio’s journey to restored sight was not an easy one. It took a dedicated team of researchers, doctors, and the support of drugmaker Krystal Biotech to develop and refine the gene therapy eyedrops. The process involved two years of research and testing in mice, followed by approvals from regulatory authorities and hospital review boards.

Dr. Sabater’s unwavering commitment to finding a solution for Antonio and other patients like him drove the team’s efforts. His persistence paid off, not just for Antonio but also for the countless others who may benefit from this groundbreaking treatment in the future.

Antonio’s mother, Yunielkys Carvajal, expressed her gratitude in an emotional interview. She praised Dr. Sabater as not just an exceptional doctor but also a kind and caring human being who provided hope when all seemed lost. When they first arrived from Cuba, Antonio’s condition worsened despite surgery to remove the scars. However, Dr. Sabater reassured the family that he would continue seeking a solution – a promise he ultimately fulfilled.

The successful use of gene therapy eyedrops in restoring Antonio’s sight represents a major breakthrough in the field of medical science. It opens the door to new possibilities for treating other eye diseases, potentially bringing hope and healing to millions of people worldwide.

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Benard McKinley: From Incarceration to Law School at Northwestern Pritzker

Kelly Taylor

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At 39 years old, Benard McKinley has transformed his life in a remarkable way. Recently released from prison in December 2023, McKinley is now preparing to start his first year at the prestigious Northwestern Pritzker School of Law in Chicago. This achievement marks a significant milestone as he becomes the first graduate from Northwestern University’s Prison Education Program (NPEP) to be accepted into any law school, let alone one with a 4% acceptance rate.

McKinley’s journey to higher education began behind the bars of Stateville Correctional Center in northern Illinois, where he completed his bachelor’s degree last year. His academic pursuit was part of NPEP, a pioneering initiative offering college-level education to incarcerated individuals. McKinley was among the first cohort to receive a bachelor’s degree from a top 10 US university while in prison, according to rankings from US News & World Report.

His life took a dramatic turn when he was sentenced at 19 to nearly a century in prison for a gang-related murder. While incarcerated, McKinley dedicated himself to studying law, aiming to challenge his own sentence and assist fellow inmates with their legal issues. His efforts in education began with earning a GED and a paralegal diploma, followed by his acceptance into the competitive NPEP program.

The process of applying to law school was rigorous and conducted from within the prison walls. McKinley prepared for the LSAT, wrote essays, and gathered recommendations with the help of NPEP tutors. His dedication paid off when, after his early release into transitional housing, he was accepted into Northwestern’s law school.

McKinley’s story is not just one of personal triumph but also highlights the transformative power of educational programs within the prison system. Sheila Bedi, a clinical law professor at Northwestern, praised McKinley’s discipline and eagerness to learn, emphasizing the potential of many others like him who could contribute positively to society if given the chance.

Looking ahead, McKinley aspires to become a civil rights lawyer and start a legal aid clinic to support marginalized communities. His journey from a teen sentenced to prison to a law student at one of the country’s top institutions is a profound testament to the possibilities that education and determination can unlock.

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Missing Pregnant Cat Found at Ottawa Airport After 11 Days

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A pregnant cat named Athena was found at the Ottawa International Airport, almost two weeks after she disappeared in the parking area. She had traveled from Winnipeg to Ottawa. The team from Furry Tales Cat Rescue discovered her around midnight on a Tuesday, and thankfully, she’s in good shape.

Volunteer Marta Burczycka from Furry Tales Cat Rescue expressed immense joy and gratitude for Athena’s safe return, highlighting her strong maternal instincts to protect her unborn kittens. The rescue operation caught attention after a helpful tip from Blake Fawcett, an employee working near the airport, who notified the rescue team.

Athena was initially sent to Ottawa on March 21 to get better veterinary care and a safe place to have her kittens. Unfortunately, she escaped when her carrier opened accidentally. For 11 days, volunteers and the rescue team worked tirelessly, setting traps and distributing flyers across the airport to find her before she gave birth.

The community effort was huge, with many airport employees and volunteers spreading the word and looking out for Athena. Janice Richard, one of the trappers, mentioned how they found Athena hungry but still pregnant, emphasizing the collective relief and happiness at her safe recovery.

The rescue story ended happily with Athena being taken care of and preparing to have her kittens in a safe and loving environment, thanks to the persistent efforts of the rescue team and the community’s support.

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America’s Youngest Teacher Started Her Career at 16

Kelly Taylor

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Shania Muhammad became a teacher at just 16 years old, after graduating from college at 15. She grew up in a home where learning was very important. She told “Good Morning America” about how her older brothers and sisters were big influences on her. They did well in school, which inspired her to do the same.

In seventh grade, her father noticed her advanced skills and started preparing her for college entrance exams. This led to her enrolling in college early and feeling like a superhero because she was so young. By 15, she was already finished with college and soon got a job offer to teach.

Muhammad waited until she was 16, so she could drive herself to work, and then started teaching 8-year-old students. These students see her as an adult and respect her, she says. In her classroom, she loves to keep the kids active with group work, presentations, and debates, creating a dynamic and engaging environment.

She encourages open communication in her class, telling her students they can talk about anything with her. Muhammad believes it’s important to have more confidence in success than in failure.

In her conversation with “Good Morning America,” Muhammad shared her view on facing the unknown with courage rather than fear. She encourages people to not hesitate and to create opportunities for themselves if they don’t already exist.

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Millions Tune In To See Conservation Group Save Seals

Kelly Taylor

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Ocean Conservation Namibia (OCN) is a group with a big heart and an important mission. Based in Namibia, a country with long, beautiful coastlines, OCN is dedicated to saving seals, especially the cute baby ones, from dangerous plastic and fishing lines.

Imagine you’re at the beach, and you see a group of seals playing and lounging around. Suddenly, you notice something’s wrong. One of the seals is stuck, tangled up in a mess of plastic or fishing line. It’s struggling and can’t get free. That’s where OCN comes in.

The team at OCN, led by Katja and Naude Dreyer, a married couple passionate about the ocean and its creatures, runs across the beach, right into the groups of seals. They’re on a mission to find any seal that’s trapped in harmful debris. Once they spot a tangled seal, they quickly and carefully cut off the entangling mess and set the seal free.

Since 2020, OCN has rescued about 3,000 seals! That’s a lot of happy, healthy seals swimming back in the ocean because of their efforts. Their rescue missions became super popular online during the pandemic. People all over the world watched their videos, feeling a bit better seeing the seals being saved during tough times.

OCN’s work is unique and impactful. Jeff Harris, a research ecologist, mentioned that the number of seals OCN saves is much higher than in other parts of the world. While he managed to free 100 sea lions in his best year, OCN often saves that many seals in just a month!

The Dreyers started OCN about twelve years ago. Initially, Naude would try to free the seals using a paddle or by grabbing them, but it was tough. Things got better when they received a special seal rescue net, making their missions easier and safer.

During the pandemic, when their kayaking business paused, they focused even more on rescuing seals. They also shared their work online, touching people’s hearts worldwide. Their video titled “Baby seal thanks his rescuers” got over a million views!

OCN not only raises awareness about the seals but also shows us the bigger problem – our oceans are filled with trash. They’ve shown that every little bit helps and that we can all do something to protect our marine life.

With donations from kind-hearted people, OCN has grown, now having a team of seven dedicated members. They’re doing more than just rescuing seals; they’re inspiring others to care about our oceans and the creatures that call them home. The Dreyers themselves have even changed their lifestyle, choosing not to eat fish and other animal products, to live in a way that respects the animals they work so hard to save.

So, Ocean Conservation Namibia is not just about saving seals; it’s about changing the way we see and treat our oceans, one rescue at a time.

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Hero Bus Driver Saves Students from Fiery Danger in New Orleans

Kevin Wells

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In a heart-stopping incident in New Orleans, a school bus driver named Kia Rousseve became a local hero when she saved nine students from a burning bus. Her quick actions turned a potentially tragic situation into a story of courage and quick thinking.

It was a regular Wednesday morning, and Rousseve was on her usual route, about to make her fifth stop, when she noticed something alarming: smoke was coming from the bus. Without a moment’s hesitation, she knew she had to act fast. “As soon as I seen the bus smoking, my instinct was get them off of the bus,” Rousseve recounted.

A little girl on the bus ran up to her and confirmed her fears, saying the bus was on fire underneath. Rousseve didn’t waste a second. She stopped the bus and made sure all the students got off safely. “I turned the bus off and got off. When I got off, the bus blew up,” she said, describing the terrifying sounds of the explosions.

Rousseve’s primary thought during the ordeal was her child, which fueled her determination to ensure the safety of all the students on board. Her employer, Community Academies of New Orleans, praised her actions as “Courage on wheels.” Having driven school buses for three years, Rousseve demonstrated experience and bravery that day.

Feeling grateful and proud, Rousseve believes a faulty alternator was the cause of the fire. She’s relieved and happy that she could save the lives of the children, as well as her own. “I feel great about saving other kids’ lives and saving my life,” she expressed, adding that she felt divine protection was at play during the emergency.

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